Turbulent Skies (2010)

When a new airplane that's equipped with a new computer that can fly the plane on its own, is about to have its first flight. But the son of the owner decides to upload more software, he doesn't bother to check if there are any viruses with it. And he also invites some potential investors to try it. So the plane appears to be working well but suddenly it veers off course and it can't be shut down. When the military learns of this and fears what if something happens if it's over a populated area; decides to shoot it down along with everyone on board. The man who built the computer whose wife is among the passengers thinks if he can get on board he might be able to shut it down and regain control of the plane. So the military using a new plane gets him on board. But what he didn't know is that both pilots are incapacitated so there's no one who can fly the plane.

Source: TMDb